I’ve been using this spray in conjunction with Settle Me liquid and Zylkene and find that the spray has an almost instant calming effect on my firework frightened pooch. Without the spray he is still quite anxious but within a minute or two of the Pet Remedy spray being used he stops panting and the trembling is greatly reduced. He also stops the incessant pacing. It’s early days as we are still on the lead up to bonfire night but I live in hope…..